Common symptoms of multiple myeloma include: Frequent infections due to a weakened immune system (a person with myeloma is referred to as being immunocompromised) Bone pain (often in the back, ribs, and hips) Kidney problems Weakness due to anemia Diagnosis: The diagnosis of multiple myeloma is suspected by finding an elevated amount of certain antibodies in the blood and urine. A bone marrow biopsy and a bone marrow aspirate (using a needle for biopsy and a syringe